منابع مشابه
Biophysical analysis of thermosensitive TRP channels with a special focus on the cold receptor TRPM8
Mammals maintain homeostatic control of their body temperature. Therefore, these organisms are expected to have adaptations that confer the ability to detect and react to both self and ambient temperature. Temperature-activated ion channels have been discovered to be the primary molecular determinants of thermosensation. The most representative group of these determinants constitutes members of...
متن کاملThermosensitive TRP ion channels mediate cytosolic calcium response in human synoviocytes.
The transient receptor potential (TRP) channels are important membrane sensors, responding to thermal, chemical, osmotic, or mechanical stimuli by activation of calcium and sodium fluxes. In this study, three distinct TRP channels were detected and their role established in mediating cytosolic free calcium concentration ([Ca(2+)](cyt)) response in tumor-derived SW982 synoviocytes and primary cu...
متن کاملTRP channels.
The TRP (Transient Receptor Potential) superfamily of cation channels is remarkable in that it displays greater diversity in activation mechanisms and selectivities than any other group of ion channels. The domain organizations of some TRP proteins are also unusual, as they consist of linked channel and enzyme domains. A unifying theme in this group is that TRP proteins play critical roles in s...
متن کاملPharmacology of TRP Channels
TRP channels are a family of ion channels involved in a plethora of physiological sensory processes. Since their discovery they have attracted the attention of academic and non-academic laboratories with the aim of developing modulators that could be used as pharmacological tools for unveiling their physiological and pathological activities, and as therapeutic compounds for intervening in TRP d...
متن کاملNeurobiology of TRP Channels
The field studying transient receptor potential (TRP) channels, while less than fifty years old, has grown precipitously in the past few decades, revealing roles for these channels across multiple organ systems and sensory modalities. Editor Tamara Luti Rosenbaum Emir, along with a multitude of authors who are experts in their fields, truly capture the scope and complexity of these channels in ...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2009
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2008.12.2919